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Therapeutic Focus

The ubiquitin and UBL pathways contain key regulators of

• cell cycle progression
•  protein quality control
•  immune response
•  nuclear export of proteins
• numerous other processes 

Dysregulation of these pathways is associated with

• neoplastic diseases (cancers)
•  neurodegenerative diseases
•  osteoporosis
•  muscle wasting/cachexia
• other diseases